Authored by: Jill Glasspool Malone, PhD
Nature Biotechnology published a paper in July, 2022 called “The COVID-19 vaccine patent race.” In this paper, Nature Biotechnology asserts that the first reduction to practice of mRNA vaccination occurred in 2000. This is patently false. It is hard to believe that this could be an accidental oversight by this scientific journal. The first in-vivo (animal) experiments reducing this mRNA vaccination to practice occurred in 1989. The first experiment was mRNA Vaccination of Mice to Produce the gp120 Protein of HIV Virus with subsequent production of gp120 antibody in the mRNA vaccinated mice, and the second experiment was mRNA Vaccination of Human Stem Cell-Bearing SCID Mice with HIV nef mRNA Followed by HIV Challenge. Both experiments were presented to the United States Patent Office and these claims were approved in nine issued patents, all with a priority date of March 21, 1989. That means that these experiments were conducted in 1989-90. These two examples and the nine patents are listed at the end of this article. Note that these patents also include extensive descriptions of the technology.
This is not the first time that the Nature journals failed to properly cite and acknowledge the early work of Dr. Malone and his other co-inventors listed on the patents as the actual inventors of the mRNA vaccine platform and technologies. In September, 2021, Nature published an article, written by Eli Dolgin that asserts that the first proof of principle experiments occurred much later in 2005. That paper was never corrected, even though Dr. Malone notified the author, Eli Dolgin about the error. Mr. Dolgin refused to even read the patents and to consider that fact that the timeline listed in that paper was incorrect. This has set up a cascade of major newspapers, journals and magazines insisting that Dr. Malone has nothing to do with the actual proof of principle mRNA vaccine experiments.
The Congressional Research Services (CRS) then put out a book for Congress entitled: “mRNA Technologies: A Primer“, published in May 2022. This is the government record on the history of mRNA vaccination and technologies. Again, the invention and timeline (the CRS taken from the Nature article above) is not just wrong, it is glaringly false. When the CRS was contacted, they refused to engage and correct their publication, a screen shot of the CRS reply is here:
The question has to be why? What is going on? The patent record is quite clear, as adjudicated by the US Patent and Trademark Office, the official government agency responsible for adjudicating and assigning inventorship. Is this merely a case of incompetent oversight and editing of a Congressional Research Service publication, or should more meaning be placed on this false time line? On the government choosing to remove the true inventors of mRNA vaccines from the congressional record? Is this as it appears? Is the government literally trying to erase the role that Dr. Robert Malone had in this invention, and write him, his work, and that of his co-inventors out of history?
Here is the CRS fabricated version of the invention. Note that the first proof of principle experiments, as documented and published by the USPTO are missing from this figure found in the CRS document.
The CRS completely wrote out the seminal proof of principle experiments as documented in the figure from their publication below. This is now the Congressional record – the US GOVERNMENT’S RECORD OF EVENTS!
So what is the correct history?
The history of the mRNA vaccines all started when Dr. Robert Malone was at the Salk Institute in 1987 and 1988 as a graduate student. There, he pioneered in-vitro RNA transfection and also in-vivo RNA transfection (in frog embryos, as well as mice).
This resulted in his seminal paper: Cationic liposome-mediated RNA transfection RW Malone, PL Felgner, IM Verma. Proceedings of the National Academy of Sciences (PNAS) 86 (16), 6077-6081
The Science paper was the first showing data for DNA and RNA side by side for in-vivo (the first paper for in-vivo DNA). That paper was published in 1990.
Direct gene transfer into mouse muscle in vivo. Wolff JA, Malone RW, et al. Science. 1990;247(4949 Pt 1):1465-8. Cited in 4,750 articles, is the result of that work.
Dr. Malone filed patent and disclosures from the Salk included in-vivo RNA transfection and also methods for mRNA stabilization – now being claimed as invented by others. These are available for review on his website.
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